The vitamin B-complex are essential water-soluble vitamins, including vitamin B1(thiamine), vitamin B2 (riboflavin ), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), biotin, folic acid and vitamin B12 (cobalamins).
A. Vitamin B1 (Thiamine)
Vitamin B1 and glucose metabolism and vascular disease
Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient. In the study to examine the mechanisms by which thiamine deficiency occurs in individuals with diabetes, how this deficiency leads to hyperglycaemic-induced damage, and the effect of thiamine replacement on vascular disease, endothelial function and oxidative stress, showed that thiamine administration can prevent the formation of harmful by-products of glucose metabolism, reduce oxidative stress and improve endothelial function. The potential benefit of long-term replacement in those with diabetes is not yet known but may reduce cardiovascular risk and angiopathic complications(20).
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Sources
(20) http://www.ncbi.nlm.nih.gov/pubmed/21564442
