Hesperidin is a Flavanones, belonging to the flavonoid in Flavonoids (polyphenols)(C28H34O15), found abundantly in citrus fruits. Health Benefits 1. Cholesterol lowering In the investigation of Hesperidin, the most important flavanone of Citrus sp., and its effect of lowering cholesterol found that hesperidin significantly increases HDL and lowers cholesterol, LDL, total lipid and triglyceride plasma levels …