The vitamin B-complex are essential water-soluble vitamins, including vitamin B1(thiamine), vitamin B2 (riboflavin ), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), biotin, folic acid and vitamin B12 (cobalamins). A. Vitamin B1 (Thiamine) ┬áVitamin B1 and neurodegenerative disease pathophysiology Emerging evidence suggests that thiamine deficiency (TD), the cause of Wernicke’s encephalopathy, produces alterations …