The prevalence of upper gastrointestinal (GI) diseases is increasing in subjects aged 65 years and over. Pathophysiological changes in esophageal functions that occur with aging may, at least in part, be responsible for the high prevalence of 1. Gastro-esophageal reflux disease (GERD) in old age. 2. The incidence of gastric and duodenal ulcers and their …